Cardiovascular adverse conditions are caused by coronavirus disease 2019 (COVID-19) infections and reported as side-effects of the COVID-19 vaccines. Enriching current vaccine safety surveillance systems with additional data sources may improve the understanding of COVID-19 vaccine safety.
Single-cell mRNA sequencing of peripheral blood mononuclear cells before and 28 days after the first inoculation revealed consistent alterations in gene expression of many different immune cell types, CD8+ T cells reduction and classic monocyte contents increase. Additional caution when vaccinating people with pre-existing clinical conditions, including diabetes, electrolyte imbalances, renal dysfunction, and coagulation disorders.
Large-scale COVID-19 vaccinations causing consistent alterations in hemoglobin A1c, serum sodium and potassium levels, coagulation profiles, and renal functions in healthy volunteers after vaccination with an inactivated SARS-CoV-2 vaccine
